Pharmacotherapy for treatment-resistant schizophrenia
Identifieur interne : 000533 ( Main/Exploration ); précédent : 000532; suivant : 000534Pharmacotherapy for treatment-resistant schizophrenia
Auteurs : Meghan E. Mcilwain [Nouvelle-Zélande] ; Jeff Harrison [Nouvelle-Zélande] ; Amanda J. Wheeler [Nouvelle-Zélande, Australie] ; Bruce R. Russell [Nouvelle-Zélande]Source :
- Neuropsychiatric Disease and Treatment [ 1176-6328 ] ; 2011.
Abstract
Schizophrenia is a disabling mental illness with a lifetime prevalence of 0.7% worldwide and significant, often devastating, consequences on social and occupational functioning. A range of antipsychotic medications are available; however, suboptimal therapeutic response in terms of psychotic symptoms is common and affects up to one-third of people with schizophrenia. Negative symptoms are generally less amenable to treatment. Because of the consequences of inadequate symptom control, effective treatment strategies are required for people with treatment-resistant schizophrenia. Clozapine has been shown to be more effective than other antipsychotics in treatment-resistant populations in several studies; however, the occurrence of adverse effects, some of which are potentially life-threatening, are important limitations. In addition to those who are intolerant to clozapine, only 30% to 50% experience clinically significant symptom improvement. This review describes the recent evidence for treatment strategies for people not responding to nonclozapine antipsychotic agents and people not responding or only partially responding to clozapine.
Url:
DOI: 10.2147/NDT.S12769
PubMed: 21552316
PubMed Central: 3083987
Affiliations:
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Adams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aleman, A" uniqKey="Aleman A">A Aleman</name></author><author><name sortKey="Sommer, Ie" uniqKey="Sommer I">IE Sommer</name></author><author><name sortKey="Kahn, Rs" uniqKey="Kahn R">RS Kahn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levy Rueff, M" uniqKey="Levy Rueff M">M Lévy-Rueff</name></author><author><name sortKey="Gourevitch, R" uniqKey="Gourevitch R">R Gourevitch</name></author><author><name sortKey="Loo, H" uniqKey="Loo H">H Lôo</name></author><author><name sortKey="Olie, J P" uniqKey="Olie J">J-P Olié</name></author><author><name sortKey="Amado, I" uniqKey="Amado I">I Amado</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>Nouvelle-Zélande</li></country></list><tree><country name="Nouvelle-Zélande"><noRegion><name sortKey="Mcilwain, Meghan E" sort="Mcilwain, Meghan E" uniqKey="Mcilwain M" first="Meghan E" last="Mcilwain">Meghan E. Mcilwain</name></noRegion><name sortKey="Harrison, Jeff" sort="Harrison, Jeff" uniqKey="Harrison J" first="Jeff" last="Harrison">Jeff Harrison</name><name sortKey="Mcilwain, Meghan E" sort="Mcilwain, Meghan E" uniqKey="Mcilwain M" first="Meghan E" last="Mcilwain">Meghan E. Mcilwain</name><name sortKey="Russell, Bruce R" sort="Russell, Bruce R" uniqKey="Russell B" first="Bruce R" last="Russell">Bruce R. Russell</name><name sortKey="Russell, Bruce R" sort="Russell, Bruce R" uniqKey="Russell B" first="Bruce R" last="Russell">Bruce R. Russell</name><name sortKey="Wheeler, Amanda J" sort="Wheeler, Amanda J" uniqKey="Wheeler A" first="Amanda J" last="Wheeler">Amanda J. Wheeler</name></country><country name="Australie"><noRegion><name sortKey="Wheeler, Amanda J" sort="Wheeler, Amanda J" uniqKey="Wheeler A" first="Amanda J" last="Wheeler">Amanda J. Wheeler</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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